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Category: Scientific Publications

NX210c Demonstrates Therapeutic Potential to Restore Blood–Brain Barrier in a QSP Model of Relapsing–Remitting Multiple Sclerosis

By bertrand

International Journal of Molecular Sciences Giulia Russo 1,2, Fianne Sips 3, Simona Catozzi 4, Pauline Bambury 4, Annette Janus 5, Mario Torchia 4, Valentina Di Salvatore 1 , Luca Emili 4, Daniel Röshammar 4,*, Francesco Pappalardo 1,2 and Yann Godfrin 5 Department of Drug and Health Sciences, Università degli Studi di Catania, 95125 Catania, Italy; … Read more

Restoring brain barriers: an innovative approach for treating neurological disorders

By bertrand

ORIGINAL RESEARCH article Fluids and Barriers of the CNS Sighild Lemarchant1, Britta Engelhardt2, Francesca Cicchetti3,4, Gregory J. Bix5,6,7,8,9, Annette Janus1, Yann Godfrin1, Hélène Blasco10, Matthew Campbell11 and Aurélie de Rus Jacquet3,4 Axoltis Pharma, 60 Avenue Rockefeller, 69008 Lyon, France. Theodor Kocher Institute, University of Bern, Bern 3012, Switzerland Centre de Recherche du CHU de Québec, … Read more

Safety, Tolerability and Pharmacokinetic‑Pharmacodynamic Relationship of NX210c Peptide in Healthy Elderly Volunteers: Randomized, Placebo‑Controlled, Double‑Blind, Multiple Ascending Dose Study

By bertrand

ORIGINAL RESEARCH article Neurology and Therapy 2024 Annette Janus1 · Daniel Dumas2,3 · Juliette Le Douce1 · Sébastien Marie1 · Giuseppe Pasculli4 · Pauline Bambury4 · Sighild Lemarchant1 · Philip Kremer2,3 · Yann Godfrin1,5 Axoltis Pharma, 60 Avenue Rockefeller, 69008 Lyon, France. Centre for Human Drug Research (CHDR), Leiden, The Netherlands Leiden University Medical Centre … Read more

NX210c drug candidate peptide strengthens mouse and human blood-brain barriers

By bertrand

RESEARCH article Fluids and Barriers of CNS, 2024 – September, 21:76 Chris Greene1, Nicolas Rebergue2, Gwen Fewell3, Damir Janigro4, Yann Godfrin2,5, Matthew Campbell1 & Sighild Lemarchant2 Smurfit Institue of Genetics, Trinity College Dublin, Lincoln Place Gate,Dublin 2, Ireland Axoltis Pharma, 60 Avenue Rockefeller, 69008 Lyon, France. SynVivo, Huntsville, AL 35806, USA Flocell Inc, Cleveland, OH … Read more

NX210c Peptide Promotes Glutamatergic Receptor‐Mediated Synaptic Transmission and Signaling in the Mouse Central Nervous System

By bertrand

ORIGINAL RESEARCH article MDPI – International journal of Molecular Sciences, 2022 – August, Vol.23. Sighild Lemarchant1, Mélissa Sourioux1, Juliette Le Douce1, Alexandre Henriques2, Noëlle Callizot2, Sandrine Hugues3, Mélissa Farinelli3 and Yann Godfrin1, 4 Axoltis Pharma, 60 Avenue Rockefeller, 69008 Lyon, France. Neuro‐Sys, 410 Chemin Départemental 60, 13120 Gardanne, France E‐Phy‐Science, Bioparc, 2400 Routes de Colles, … Read more

Safety, Tolerability, Pharmacokinetics and Initial Pharmacodynamics of a Subcommissural Organ- Spondin-Derived Peptide: A Randomized, Placebo- Controlled, Double-Blind, Single Ascending Dose Firstin- Human Study

By bertrand

ORIGINAL RESEARCH article Neurology and Therapy, 2022 – July, Vol.11. Valérie Bourdès1 . Peter Dogterom2 . André Aleman3 . Pierre Parmantier4 . Damien Colas4 . Sighild Lemarchant1 . Sébastien Marie1 . Thomas Chou5 . Khalid Abd-Elaziz2 . Yann Godfrin1, 6 Axoltis Pharma, 60 Avenue Rockefeller, 69008 Lyon, France QPS Netherlands B.V., Groningen, The Netherlands Department … Read more

SCO-spondin-derived Peptide Protects Neurons from Glutamate-induced Excitotoxicity

By bertrand

ORIGINAL RESEARCH article NEUROSCIENCE, 2021 – May; Vol.463. Nathalie Delétage1, Juliette Le Douce 1, Noëlle Callizot 2, Yann Godfrin 1,3, Sighild Lemarchant 1 Axoltis Pharma, 60 Avenue Rockefeller, 69008 Lyon, France. Neuro-Sys, 410 Chemin Départemental 60, 13120 Gardanne, France. Godfrin Life Sciences, 8 impasse de la source, 69300 Caluire-et-Cuire, France.